The mechanisms involved in local induced inflammation can be studied using several
available animal models. One of these is the induction of apical periodontitis (AP). Apical
periodontitis is a common pathology of an inflammatory nature in the periodontal tissues
surrounding the tooth root. In order to better understand the nature and mechanism of this
pathology it is advantageous to perform the procedure in mice. The induction of this
odontogenic inflammation is achieved by drilling into the mouse tooth until the dental pulp is …