Influence of CYP450 enzymes, CES1, PON1, ABCB1, and P2RY12 polymorphisms on clopidogrel response in patients subjected to a percutaneous neurointervention
M Saiz-Rodríguez, C Belmonte, JL Caniego… - Clinical Therapeutics, 2019 - Elsevier
Purpose Clopidogrel is a thienopyridine prodrug that inhibits platelet aggregation. It is
prescribed to prevent atherothrombotic and thromboembolic events in patients receiving a
stent implant in carotid, vertebral, or cranial arteries. The influence of cytochrome P-450
(CYP) 2C19 on the response to clopidogrel has been widely studied; however, the effect of
other genes involved in clopidogrel absorption and metabolism has not been established in
this cohort of patients. Methods This observational retrospective study assessed the …
prescribed to prevent atherothrombotic and thromboembolic events in patients receiving a
stent implant in carotid, vertebral, or cranial arteries. The influence of cytochrome P-450
(CYP) 2C19 on the response to clopidogrel has been widely studied; however, the effect of
other genes involved in clopidogrel absorption and metabolism has not been established in
this cohort of patients. Methods This observational retrospective study assessed the …
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