Influence of age or circadian time on bcl-2 and bax mRNA expression in the rat hippocampus after corticosterone exposure
A Yoshimura, A Masui, S Jinde, H Kanai, N Kato… - Brain research …, 2007 - Elsevier
A rapid elevation in the level of endogenous corticosterone (CORT) functions in the stress
response associated with the hypothalamus–pituitary–adrenal axis, and it has been well
documented that high levels of CORT play neurotoxic roles in the hippocampus. Both aging
and the circadian rhythm possibly affect the sensitivity to CORT, although their endogenous
modifications in the CORT-mediated events remain unclear. To explore the influence of age
or circadian time on hippocampal vulnerability to excess CORT, we examined the relative …
response associated with the hypothalamus–pituitary–adrenal axis, and it has been well
documented that high levels of CORT play neurotoxic roles in the hippocampus. Both aging
and the circadian rhythm possibly affect the sensitivity to CORT, although their endogenous
modifications in the CORT-mediated events remain unclear. To explore the influence of age
or circadian time on hippocampal vulnerability to excess CORT, we examined the relative …
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