Objective.—To develop valid and reliable instruments to assess the methodologic quality
and clinical relevance of drug studies. Design.—We developed an instrument to assess the
methodologic quality of articles reporting clinical research and an instrument to measure
nonmethodologic measures of quality, such as clinical relevance, generalizability, and
adherence to ethical standards. Each instrument was pretested by seven independent,
masked reviewers and modified based on interrater agreement and content validity of …