[HTML][HTML] Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells …
E Di Consiglio, F Pistollato, E Mendoza-De Gyves… - Reproductive …, 2020 - Elsevier
For some complex toxicological endpoints, chemical safety assessment has conventionally
relied on animal testing. Apart from the ethical issues, also scientific considerations have
been raised concerning the traditional approach, highlighting the importance for considering
real life exposure scenario. Implementation of flexible testing strategies, integrating multiple
sources of information, including in vitro reliable test methods and in vitro biokinetics, would
enhance the relevance of the obtained results. Such an approach could be pivotal in the …
relied on animal testing. Apart from the ethical issues, also scientific considerations have
been raised concerning the traditional approach, highlighting the importance for considering
real life exposure scenario. Implementation of flexible testing strategies, integrating multiple
sources of information, including in vitro reliable test methods and in vitro biokinetics, would
enhance the relevance of the obtained results. Such an approach could be pivotal in the …
以上显示的是最相近的搜索结果。 查看全部搜索结果