[HTML][HTML] Interleukin 33 as a mechanically responsive cytokine secreted by living cells
Interleukin 33 (IL-33), a member of the Interleukin 1 cytokine family, is implicated in
numerous human inflammatory diseases such as asthma, atherosclerosis, and rheumatoid
arthritis. Despite its pathophysiologic importance, fundamental questions regarding the
basic biology of IL-33 remain. Nuclear localization and lack of an export signal sequence
are consistent with the view of IL-33 as a nuclear factor with the ability to repress RNA
transcription. However, signaling via the transmembrane receptor ST2 and documented …
numerous human inflammatory diseases such as asthma, atherosclerosis, and rheumatoid
arthritis. Despite its pathophysiologic importance, fundamental questions regarding the
basic biology of IL-33 remain. Nuclear localization and lack of an export signal sequence
are consistent with the view of IL-33 as a nuclear factor with the ability to repress RNA
transcription. However, signaling via the transmembrane receptor ST2 and documented …
Interleukin 33 as a mechanically responsive cytokine secreted by living cells
R Kakkar, H Hei, S Dobner… - The Thoracic and …, 2014 - thieme-connect.com
Background: Interleukin 33 (IL-33), a member of the Interleukin 1 cytokine family, is
implicated in numerous human inflammatory diseases such as asthma, atherosclerosis and
rheumatoid arthritis. Despite its pathophysiologic importance, fundamental questions
regarding the basic biology of IL-33 remain. Nuclear localization and lack of an export signal
sequence are consistent with the view of IL-33 as a nuclear factor with the ability to repress
RNA transcription. However, signaling via the transmembrane receptor ST2 and …
implicated in numerous human inflammatory diseases such as asthma, atherosclerosis and
rheumatoid arthritis. Despite its pathophysiologic importance, fundamental questions
regarding the basic biology of IL-33 remain. Nuclear localization and lack of an export signal
sequence are consistent with the view of IL-33 as a nuclear factor with the ability to repress
RNA transcription. However, signaling via the transmembrane receptor ST2 and …
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