… IL-15 signaling in autoimmunity. Unlike therapies targeting other … of IL-15 signaling in
autoimmunity and explore potential … role of IL-15 in autoimmune diseases and the complexities of …

… of these autoimmune diseases. … autoimmune disease: new therapeutic targets are needed.
Recently, disorders involving interleukin-15 (IL-15) have been shown in such autoimmune …

IL-15, a pleiotropic cytokine, stimulates generation of NK, NK-T, γδ, ILC1, and memory CD8
T cells. IL-15 disorders play pathogenetic roles in organ-specific autoimmune diseases …

… role for IL-15 in autoimmune type 1 diabetes. In other autoimmune diseases, such as … of
CD8 + T cells, which in turn perpetuate the autoimmune inflammatory process [7, 8]. Our findings …

… A role for IL-15 during autoimmune processes such as rheumatoid arthritis and malignancies
such as adult T-cell leukemia suggest that dysregulation of IL-15 may result in deleterious …

Several cytokines are involved in the complex processes ultimately leading to autoimmune
diseases. In a preceding review, we have already discussed the role of the IL-12 and -17 …

… Interleukin 15 participates in the development of important immune antitumor mechanisms.
… autoimmunity and promotion of proliferation, survival, and dissemination of some tumor cells. …

… Functional characterization of the human interleukin15 receptor alpha chain and close …
Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of …

… Interleukin-2 and interleukin-15 have pivotal roles in the control of the life and death of …
-reactive T cells to prevent autoimmunity. By contrast, interleukin-15 is dedicated to the prolonged …

… IL-15 therapy is useful for controlling the experimental autoimmune … IL-15 greatly influences
autoimmune diseases, inflammatory disorders, … Novel human interleukin-15 agonists …