The global human population has recently experienced an increase in life expectancy with a
mounting concern about the steady rise in the incidence of age-associated chronic diseases
and socio-economic burden. Calorie restriction (CR), the reduction of energy intake without
malnutrition, is a dietary manipulation that can increase health and longevity in most model
organisms. However, the practice of CR in day-to-day life is a challenging long-term goal for
human intervention. Recently, daily fasting length and periodicity have emerged as potential …

Classic implementation of calorie restriction (CR) in laboratory animals increases health and
longevity in most model organisms. Traditionally, chronic CR is the reduction of daily energy
intake without malnutrition. Recently, paradigms have emerged that recapitulate some of the
beneficial aspects of this intervention, avoiding some of its challenges. The length of daily
fasting length and periodicity have emerged as potential drivers behind CR's beneficial
health effects. Numerous strategies and eating patterns, including prolonged periods of …