Investigating post-translational modifications in neuropsychiatric disease: The next frontier in human post-mortem brain research
MJ Grubisha, RA Sweet… - Frontiers in Molecular …, 2021 - frontiersin.org
Frontiers in Molecular Neuroscience, 2021•frontiersin.org
Gene expression and translation have been extensively studied in human post-mortem
brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs)
have received less attention despite their implication by unbiased genetic studies and
importance in regulating neuronal and circuit function. Here we review the rationale for
studying PTMs in psychiatric disease, recent findings in human post-mortem tissue, the
required controls for these types of studies, and highlight the emerging mass spectrometry …
brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs)
have received less attention despite their implication by unbiased genetic studies and
importance in regulating neuronal and circuit function. Here we review the rationale for
studying PTMs in psychiatric disease, recent findings in human post-mortem tissue, the
required controls for these types of studies, and highlight the emerging mass spectrometry …
Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic studies and importance in regulating neuronal and circuit function. Here we review the rationale for studying PTMs in psychiatric disease, recent findings in human post-mortem tissue, the required controls for these types of studies, and highlight the emerging mass spectrometry approaches transforming this research direction.
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