Dual-specificity protein phosphatase 5 (DUSP5) is a member of the tyrosine-threonine
phosphatase family with the ability to dephosphorylate and inactivate extracellular signal-
related kinase (ERK). The present study investigates whether knockout (KO) of Dusp5
improves renal hemodynamics and protects against hypertension-induced renal injury. The
renal expression of DUSP5 was reduced, and the levels of phosphorylated (p) ERK1/2 and
p-protein kinase C (PKC) α were elevated in the KO rats. KO of Dusp5 enhanced the …

Dual-specificity protein phosphatase 5 (Dusp5) is a member of serine-threonine
phosphatase family that regulates intracellular signal transduction by dephosphorylating
ERK1/2. We previously generated Dusp5 zinc-finger knockout (KO) rats and found that KO of
Dusp5 enhances myogenic response of middle cerebral artery and autoregulation of
cerebral blood flow. This study investigated whether Dusp5 KO also improves renal
hemodynamics and protects against hypertension-induced chronic kidney disease (CKD) …