Left frontoparietal network activity is modulated by drug stimuli in cocaine addiction

V Costumero, P Rosell-Negre, JC Bustamante… - Brain imaging and …, 2018 - Springer
V Costumero, P Rosell-Negre, JC Bustamante, P Fuentes-Claramonte, JJ Llopis, C Ávila
Brain imaging and behavior, 2018Springer
Cocaine addicts present reduced activity in the left frontoparietal network, a brain network
associated with cognitive control, during the processing of non-drug reward related stimuli
(Costumero et al., Addiction Biology 22: 479–489, 2015). However, the involvement of this
network in drug-related stimuli processing remains unclear. Here, fifteen cocaine-dependent
men and fifteen healthy matched controls viewed cocaine-related, erotic, aversive, and
neutral pictures during an fMRI session. Group independent component analysis was then …
Abstract
Cocaine addicts present reduced activity in the left frontoparietal network, a brain network associated with cognitive control, during the processing of non-drug reward related stimuli (Costumero et al., Addiction Biology 22:479–489, 2015). However, the involvement of this network in drug-related stimuli processing remains unclear. Here, fifteen cocaine-dependent men and fifteen healthy matched controls viewed cocaine-related, erotic, aversive, and neutral pictures during an fMRI session. Group independent component analysis was then performed to investigate how functional networks were modulated by the different emotional images. The results showed that the cocaine-dependent group showed stronger left frontoparietal network activity during the processing of cocaine-related pictures than the control group. Furthermore, the activity of this network during cocaine image processing was positively associated with the years of cocaine use in addicted subjects. In conclusion, our results indicate that the left frontoparietal network is affected in cocaine-dependent men, and may be related to the cognitive control deficits shown in addiction.
Springer
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