siRNA therapeutics have promise for the treatment of a wide range of genetic disorders.
Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA
carriers with a wide therapeutic index. Lead material cKK-E12 showed potent silencing
effects in mice (ED50∼ 0.002 mg/kg), rats (ED50< 0.01 mg/kg), and nonhuman primates
(over 95% silencing at 0.3 mg/kg). Apolipoprotein E plays a significant role in the potency of
cKK-E12 both in vitro and in vivo. cKK-E12 was highly selective toward liver parenchymal …

Erratum: Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and
nonhuman primates (Proceedings of the National Academy of Sciences of the United States
of America (2014) 111:11 (3955-3960) DOI:10.1073/pnas.1322937111) — The Ohio State
University … Erratum: Lipopeptide nanoparticles for potent and selective siRNA delivery in
rodents and nonhuman primates (Proceedings of the National Academy of Sciences of the
United States of America (2014) 111:11 (3955-3960) DOI:10.1073/pnas.1322937111) …