Local sympathectomy promotes anti-inflammatory responses and relief of paclitaxel-induced mechanical and cold allodynia in mice
Background Patients undergoing cancer treatment often experience chemotherapy-induced
neuropathic pain at their extremities, for which there is no US Food and Drug Administration–
approved drug. The authors hypothesized that local sympathetic blockade, which is used in
the clinic to treat various pain conditions, can also be effective to treat chemotherapy-
induced neuropathic pain. Methods A local sympathectomy (ie, cutting the ipsilateral gray
rami entering the spinal nerves near the L3 and L4 dorsal root ganglia) was performed in …
neuropathic pain at their extremities, for which there is no US Food and Drug Administration–
approved drug. The authors hypothesized that local sympathetic blockade, which is used in
the clinic to treat various pain conditions, can also be effective to treat chemotherapy-
induced neuropathic pain. Methods A local sympathectomy (ie, cutting the ipsilateral gray
rami entering the spinal nerves near the L3 and L4 dorsal root ganglia) was performed in …
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