Low dopamine D2 receptor increases vulnerability to obesity via reduced physical activity, not increased appetitive motivation
Background The dopamine D 2 receptor (D 2 R) has received much attention in obesity
studies. Data indicate that D 2 R is reduced in obesity and that the TaqA1 D 2 R variant may
be more prevalent among obese persons. It is often suggested that reduced D 2 R
generates a reward deficiency and altered appetitive motivation that induces compulsive
eating and contributes to obesity. Although dopamine is known to regulate physical activity,
it is often neglected in these studies, leaving open the question of whether reduced D 2 R …
studies. Data indicate that D 2 R is reduced in obesity and that the TaqA1 D 2 R variant may
be more prevalent among obese persons. It is often suggested that reduced D 2 R
generates a reward deficiency and altered appetitive motivation that induces compulsive
eating and contributes to obesity. Although dopamine is known to regulate physical activity,
it is often neglected in these studies, leaving open the question of whether reduced D 2 R …
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