Lowering dietary n-6 polyunsaturated fatty acids: interaction with brain arachidonic and docosahexaenoic acids
SM Alashmali, KE Hopperton… - Current opinion in …, 2016 - journals.lww.com
SM Alashmali, KE Hopperton, RP Bazinet
Current opinion in lipidology, 2016•journals.lww.com… This review will evaluate the effect of lowering dietary n-6 PUFA on levels and
metabolism of ARA and DHA in animal models and in humans, with a primary focus on the
brain. … As n-6 PUFA are more abundant in the diet than n-3 PUFA (Canadians consume a
ratio of 7–8 : 1 linoleic acid to ALA, and similar intakes have been noted around the world) [5,6]
, there is great opportunity to change the fatty acid composition of the diet by targeting n-6
PUFA. The aim of the present article is to review the literature on the effect of lowering …
metabolism of ARA and DHA in animal models and in humans, with a primary focus on the
brain. … As n-6 PUFA are more abundant in the diet than n-3 PUFA (Canadians consume a
ratio of 7–8 : 1 linoleic acid to ALA, and similar intakes have been noted around the world) [5,6]
, there is great opportunity to change the fatty acid composition of the diet by targeting n-6
PUFA. The aim of the present article is to review the literature on the effect of lowering …
Summary
Lowering dietary n-6 PUFA, in animal models, can alter the levels and metabolism of ARA and DHA in the brain, but it remains to be determined whether these changes are clinically meaningful.
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