MAP kinase pathways activated by stress: the p38 MAPK pathway
T Obata, GE Brown, MB Yaffe - Critical care medicine, 2000 - journals.lww.com
A stress-activated serine/threonine protein kinase, p38 mitogen-activated protein kinase
(p38 MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including
ultraviolet light, irradiation, heat shock, high osmotic stress, proinflammatory cytokines and
certain mitogens, trigger a stress-regulated protein kinase cascade culminating in activation
of p38 MAPK through phosphorylation on a TGY motif within the kinase activation loop. p38
MAPK appears to play a major role in apoptosis, cytokine production, transcriptional …
(p38 MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including
ultraviolet light, irradiation, heat shock, high osmotic stress, proinflammatory cytokines and
certain mitogens, trigger a stress-regulated protein kinase cascade culminating in activation
of p38 MAPK through phosphorylation on a TGY motif within the kinase activation loop. p38
MAPK appears to play a major role in apoptosis, cytokine production, transcriptional …
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