Mechanisms of hepatotoxicity
H Jaeschke, GJ Gores, AI Cederbaum… - Toxicological …, 2002 - academic.oup.com
… In summary, several mechanisms initiate liver cell damage and aggravate ongoing injury
processes. Mitochondria are prominent targets for the hepatotoxicity of many drugs. …
processes. Mitochondria are prominent targets for the hepatotoxicity of many drugs. …
Hepatotoxicity: molecular mechanisms and pathophysiology
R Teschke - International journal of molecular sciences, 2019 - mdpi.com
The current Special Issue is devoted to the broad spectrum of hepatotoxicity with its molecular
mechanisms and pathophysiology, presented in eight publications [1–8]. Scientists were …
mechanisms and pathophysiology, presented in eight publications [1–8]. Scientists were …
Mechanisms of drug-induced hepatotoxicity
AI Shehu, X Ma, R Venkataramanan - Clinics in liver disease, 2017 - liver.theclinics.com
Drug-induced hepatotoxicity (DIH) is an important clinical problem in the United States and
around the world. It is one of the primary reasons for failure of drug candidates during …
around the world. It is one of the primary reasons for failure of drug candidates during …
In vitro investigation of the molecular mechanisms of hepatotoxicity
JV Castell, MJ Gómez-Lechón, X Ponsoda… - … Through Basic Science …, 1997 - Springer
… mechanisms). Ultimately, it is the balance between bioactivation, detoxification and defense
mechanisms … Studies on hepatotoxicity most frequently deal with a type of cell death which is …
mechanisms … Studies on hepatotoxicity most frequently deal with a type of cell death which is …
Current concepts of mechanisms in drug-induced hepatotoxicity
S Russmann, GA Kullak-Ublick… - Current medicinal …, 2009 - ingentaconnect.com
… model that limits its principle mechanisms to three main ways of … For all mechanisms,
mitochondria play a central role in … a better understanding of mechanisms in hepatotoxicity, and to …
mitochondria play a central role in … a better understanding of mechanisms in hepatotoxicity, and to …
Hepatotoxicity: mechanisms of liver injury
MG Neuman - Liver diseases: a multidisciplinary textbook, 2020 - Springer
… Toxic liver disease, hepatotoxicity, encompasses numerous … to detection and assessment of
hepatotoxicity induced by human … detection requirements of hepatotoxicity caused by natural …
hepatotoxicity induced by human … detection requirements of hepatotoxicity caused by natural …
Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism (s): a critical discussion
DK Ingawale, SK Mandlik, SR Naik - Environmental toxicology and …, 2014 - Elsevier
… understand the mechanism (s) and to establish their correlation with in vivo hepatotoxicity
(… The current review focus and discuss on probable mechanism(s) of hepatotoxicity due to …
(… The current review focus and discuss on probable mechanism(s) of hepatotoxicity due to …
Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved
T Martínez-Sena, E Moro, M Moreno-Torres… - Archives of …, 2023 - Springer
… accounting for global hepatotoxicity and mechanisms-related … predominant mechanisms
of toxicity and 18 non-hepatotoxic … signatures for each mechanism of hepatotoxicity. The …
of toxicity and 18 non-hepatotoxic … signatures for each mechanism of hepatotoxicity. The …
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
B Fromenty, D Pessayre - Pharmacology & therapeutics, 1995 - Elsevier
Severe and prolonged impairment of mitochondrial β-oxidation leads to microvesicular
steatosis, and, in severe forms, to liver failure, coma and death. Impairment of mitochondrial β-…
steatosis, and, in severe forms, to liver failure, coma and death. Impairment of mitochondrial β-…
[HTML][HTML] Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology
A Ramachandran, H Jaeschke - Journal of clinical and translational …, 2017 - ncbi.nlm.nih.gov
… in the United States and mechanisms of liver injury induced by … , have shown that hepatotoxicity
is initiated by formation of a … the mechanisms behind APAP-induced hepatotoxicity and …
is initiated by formation of a … the mechanisms behind APAP-induced hepatotoxicity and …