Cellular and genetic mechanisms of self tolerance and autoimmunity
… mechanisms have evolved to control the activity of these ‘forbidden’ receptors and achieve
immunological self tolerance… cellular and gene maps of self tolerance and immunity will guide …
immunological self tolerance… cellular and gene maps of self tolerance and immunity will guide …
Mechanisms of self tolerance
G Kroemer, C Martínez-A - Immunology today, 1992 - cell.com
… This notion also applies to the establishment and maintenance of tolerance to self antigens.
Thus, immune homeostasis is attributed to multiple distinct safety valves that are connected …
Thus, immune homeostasis is attributed to multiple distinct safety valves that are connected …
Cellular mechanisms of self-tolerance
CC Goodnow - Current Opinion in Immunology, 1989 - Elsevier
… @ for self-antigen on the one hand, and on the nature of the self-… mechanism of self tolerance
has been the technical d&&y … of individual clones of potentially self-reactive lymphocytes. …
has been the technical d&&y … of individual clones of potentially self-reactive lymphocytes. …
Mechanisms of self-tolerance
N Crispe - Immunology Today, 1988 - Elsevier
… conditions needed to induce tolerance, but it has often been … The state of the art in tolerance
mechanisms was the main … clonal deletion and other possible tolerance mechanisms. …
mechanisms was the main … clonal deletion and other possible tolerance mechanisms. …
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes …
S Sakaguchi, N Sakaguchi, M Asano… - Journal of immunology …, 1995 - journals.aai.org
… to maintaining self-tolerance by down-regulating immune response to self and non-self Ags
in an … immune responses to non-self Ags, but also eliciting autoimmune responses to certain …
in an … immune responses to non-self Ags, but also eliciting autoimmune responses to certain …
A fail-safe mechanism for maintaining self-tolerance.
S Guerder, P Matzinger - The Journal of experimental medicine, 1992 - rupress.org
Using cytotoxic T lymphocyte (CTL) responses to the class I histocompatibility antigen Qa1
and to the minor histocompatibility antigen HY, we show that the immune system maintains a …
and to the minor histocompatibility antigen HY, we show that the immune system maintains a …
Tolerance: an overview and perspectives
H Waldmann - Nature Reviews Nephrology, 2010 - nature.com
… Strategies that override tolerance might enable more … of self tolerance consistent with 'health'.
The first part of this Review summarizes what is known about mechanisms of self tolerance. …
The first part of this Review summarizes what is known about mechanisms of self tolerance. …
Normal mechanisms for self-tolerance
Y Iwatani, M Watanabe - Autoimmune endocrinopathies, 1999 - Springer
… They are positively managed in the periphery by the fail-safe mechanism … mechanism
is termed “peripheral tolerance.” The failure in these mechanisms of immunological self-tolerance …
is termed “peripheral tolerance.” The failure in these mechanisms of immunological self-tolerance …
Adaptive tolerance: Protection through self‐recognition
T Amendt, H Jumaa - BioEssays, 2022 - Wiley Online Library
… IgM that protects its respective self-targets from degradation. We refer to this novel mechanism
as adaptive tolerance. This article discusses the discovery of adaptive tolerance and the …
as adaptive tolerance. This article discusses the discovery of adaptive tolerance and the …
Acquisition of immunologic self-tolerance
RH Schwartz - Cell, 1989 - Elsevier
… anti-self receptors. This process is referred to as the acquisition of self-tolerance. Recent …
explore the mechanisms by which self-tolerance takes place, are the subject of this review. …
explore the mechanisms by which self-tolerance takes place, are the subject of this review. …