Rapidly increasing water contamination has turned into a major threat globally. The pollutants such as organic and inorganic compounds, heavy metals, and biological organisms are among the major contributor to water pollution. Therefore, the removal of these contaminants has attracted the researchers a lot. Various methodologies are being carried out for the purpose. Among them, the metal-organic frameworks (MOFs) with several active sites and tailorable porous architectures as adsorbents or photocatalytic removal agents is a fast-growing class of coordination chemistry to remove these agents from water. To date, numerous approaches dealing with water treatment including conservative and advanced technologies have been presented. This article thoroughly reviews the application of MOFs toward how to remove the toxic agents from water. The leading objective is to present up-to-date information and references regarding MOFs based materials toward wastewater treatment applications.