Cocaine administration has been shown to produce immediate positive (rewarding) and
subsequent negative (anxiogenic) effects in humans and animals. These dual and opposing
affective responses have been more difficult to demonstrate with administration of
methamphetamine (meth). While animal studies have reliably demonstrated the positive
reinforcing effects of the drug, reports of negative aftereffects following acute exposure have
been few in number and contradictory in nature. The current research was devised to assess …