Mice cloned from olfactory sensory neurons
Nature, 2004•nature.com
Cloning by nuclear transplantation has been successfully carried out in various mammals,
including mice. Until now mice have not been cloned from post-mitotic cells such as
neurons. Here, we have generated fertile mouse clones derived by transferring the nuclei of
post-mitotic, olfactory sensory neurons into oocytes. These results indicate that the genome
of a post-mitotic, terminally differentiated neuron can re-enter the cell cycle and be
reprogrammed to a state of totipotency after nuclear transfer. Moreover, the pattern of …
including mice. Until now mice have not been cloned from post-mitotic cells such as
neurons. Here, we have generated fertile mouse clones derived by transferring the nuclei of
post-mitotic, olfactory sensory neurons into oocytes. These results indicate that the genome
of a post-mitotic, terminally differentiated neuron can re-enter the cell cycle and be
reprogrammed to a state of totipotency after nuclear transfer. Moreover, the pattern of …
Abstract
Cloning by nuclear transplantation has been successfully carried out in various mammals, including mice. Until now mice have not been cloned from post-mitotic cells such as neurons. Here, we have generated fertile mouse clones derived by transferring the nuclei of post-mitotic, olfactory sensory neurons into oocytes. These results indicate that the genome of a post-mitotic, terminally differentiated neuron can re-enter the cell cycle and be reprogrammed to a state of totipotency after nuclear transfer. Moreover, the pattern of odorant receptor gene expression and the organization of odorant receptor genes in cloned mice was indistinguishable from wild-type animals, indicating that irreversible changes to the DNA of olfactory neurons do not accompany receptor gene choice.
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