Studies have shown that microRNA-148a (miR-148a) was proved to be silenced while DNA
methyltransferase 1 (DNMT1) was over-expressed in gastric cancer. But the mechanism of
aberrant expression of miR-148a and DNMT1 and their relationships in gastric cancer are
still unknown. The aims of this study were to investigate the expression profile of miR-148a
and DNMT1 and reveal whether they have any relationships. We used reverse-transcriptase
quantitative real-time PCR, methylation-specific PCR and Western blot to measure the level …

In general, microRNAs, a class of small (~ 21 nucleotide) non-coding RNAs, negatively
regulate the expression of their target genes. Dysregulation of miRNAs is a common feature
in human cancers, but this phenomenon has not been studied extensively in hepatocellular
carcinoma (HCC). miR‑148a, a member of the miR-148/152 family, has been found to be
downregulated in several tumor types and has been suggested to be a tumor suppressor
gene; however, its function in HCC remains unclear. Herein, we describe the epigenetic …