Mifepristone antagonization requires real studies to evaluate safety and efficacy
MD Creinin, MJ Chen - Contraception, 2019 - contraceptionjournal.org
The modern era of medical abortion treatment evolved with the development of mifepristone,
a progesterone-receptor antagonist with an affinity for the receptor greater than
progesterone itself [1]. Early studies of modern medical abortion regimens evaluated
mifepristone alone, primarily at very early gestations. Continued research demonstrated that
adding a prostaglandin analogue within a few days after mifepristone significantly improved
the efficacy of the treatment [2]. The current FDA-approved regimen of mifepristone 200 mg …
a progesterone-receptor antagonist with an affinity for the receptor greater than
progesterone itself [1]. Early studies of modern medical abortion regimens evaluated
mifepristone alone, primarily at very early gestations. Continued research demonstrated that
adding a prostaglandin analogue within a few days after mifepristone significantly improved
the efficacy of the treatment [2]. The current FDA-approved regimen of mifepristone 200 mg …
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