Fifty percent of trauma patients who present sepsis-like syndrome do not have bacterial
infections. This condition is known as systemic inflammatory response syndrome (SIRS). A
unifying factor of SIRS and sepsis is cardiovascular collapse. Trauma and severe blood loss
cause the release of endogenous molecules known as damage-associated molecular
patterns. Mitochondrial N-formyl peptides (F-MIT) are damage-associated molecular
patterns that share similarities with bacterial N-formylated peptides and are potent immune …

Fifty percent of trauma patients that present sepsis-like syndrome do not have bacterial 25
infections. This condition is known as systemic inflammatory response syndrome (SIRS). A
26 unifying factor of SIRS and sepsis is cardiovascular collapse. Trauma and severe blood
27 loss cause the release of endogenous molecules known as damage-associated
molecular 28 patterns (DAMPs). Mitochondrial N-formyl peptides (F-MIT) are DAMPs that
share 29 similarities with bacterial N-formylated peptides, and are potent immune system …