Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome
NA Bracey, B Gershkovich, J Chun, A Vilaysane… - Journal of Biological …, 2014 - ASBMB
Nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) is a pattern
recognition receptor that is implicated in the pathogenesis of inflammation and chronic
diseases. Although much is known regarding the NLRP3 inflammasome that regulates
proinflammatory cytokine production in innate immune cells, the role of NLRP3 in non-
professional immune cells is unclear. Here we report that NLRP3 is expressed in cardiac
fibroblasts and increased during TGFβ stimulation. NLRP3-deficient cardiac fibroblasts …
recognition receptor that is implicated in the pathogenesis of inflammation and chronic
diseases. Although much is known regarding the NLRP3 inflammasome that regulates
proinflammatory cytokine production in innate immune cells, the role of NLRP3 in non-
professional immune cells is unclear. Here we report that NLRP3 is expressed in cardiac
fibroblasts and increased during TGFβ stimulation. NLRP3-deficient cardiac fibroblasts …
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