Modulatory effects of extracts of vinegar-baked Radix Bupleuri and saikosaponins on the activity of cytochrome P450 enzymes in vitro
T Yu, X Chen, Y Wang, R Zhao, S Mao - Xenobiotica, 2014 - Taylor & Francis
In this article, the modulatory effects of extracts from vinegar-baked Radix Bupleuri (VBRB)
and saikosaponins on the activity of CYP1A2, CYP2C9 and CYP3A4 were investigated in
vitro. 2. Microsomal in vitro incubation method was utilized to simulate metabolic reaction
under physiological environment by incubating the marker with liver microsomes in the
absence or presence of VBRB and saikosaponins. The contents of 4-acetamidophenol, 6β-
hydroxyltestosterone and 4-hydroxydiclofenac, the metabolites of phenacetin, testosterone …
and saikosaponins on the activity of CYP1A2, CYP2C9 and CYP3A4 were investigated in
vitro. 2. Microsomal in vitro incubation method was utilized to simulate metabolic reaction
under physiological environment by incubating the marker with liver microsomes in the
absence or presence of VBRB and saikosaponins. The contents of 4-acetamidophenol, 6β-
hydroxyltestosterone and 4-hydroxydiclofenac, the metabolites of phenacetin, testosterone …
Modulatory effects of extracts of vinegar-baked Radix Bupleuri and saikosaponins on the activity of cytochrome P450 enzymes in vitro.
YTY Yu TongYa, CXZ Chen XianZhi, WYJ Wang YinJie… - 2014 - cabidigitallibrary.org
In this article, the modulatory effects of extracts from vinegar-baked Radix Bupleuri (VBRB)
and saikosaponins on the activity of CYP1A2, CYP2C9 and CYP3A4 were investigated in
vitro. Microsomal in vitro incubation method was utilized to simulate metabolic reaction
under physiological environment by incubating the marker with liver microsomes in the
absence or presence of VBRB and saikosaponins. The contents of 4-acetamidophenol, 6β-
hydroxyltestosterone and 4-hydroxydiclofenac, the metabolites of phenacetin, testosterone …
and saikosaponins on the activity of CYP1A2, CYP2C9 and CYP3A4 were investigated in
vitro. Microsomal in vitro incubation method was utilized to simulate metabolic reaction
under physiological environment by incubating the marker with liver microsomes in the
absence or presence of VBRB and saikosaponins. The contents of 4-acetamidophenol, 6β-
hydroxyltestosterone and 4-hydroxydiclofenac, the metabolites of phenacetin, testosterone …
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