Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum
JS Fink, DR Weaver, SA Rivkees, RA Peterfreund… - Molecular Brain …, 1992 - Elsevier
A cDNA fragment homologous to other G protein-coupled receptors was isolated from rat
brain using the PCR method and demonstrated to be abundantly expressed in striatum.
Using this fragment as a probe, a 2.1 kb full-length cDNA was isolated from a rat striatal
cDNA library. This cDNA encodes a protein of 410 amino acids and is highly homologous to
previously isolated adenosine receptor cDNAs. Expression of this cDNA in COS cells
revealed high affinity (K d= 38.6 nM) and saturable binding of the A 2 adenosine receptor …
brain using the PCR method and demonstrated to be abundantly expressed in striatum.
Using this fragment as a probe, a 2.1 kb full-length cDNA was isolated from a rat striatal
cDNA library. This cDNA encodes a protein of 410 amino acids and is highly homologous to
previously isolated adenosine receptor cDNAs. Expression of this cDNA in COS cells
revealed high affinity (K d= 38.6 nM) and saturable binding of the A 2 adenosine receptor …
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