Molecular identification of rare FY* Null and FY* X alleles in Caucasian thalassemic family from Sardinia
S Manfroi, A Scarcello, P Pagliaro - Transfusion and Apheresis Science, 2015 - Elsevier
Molecular genetic studies on Duffy blood group antigens have identified mutations
underlying rare FY* Null and FY* X alleles. FY* Null has a high frequency in Blacks,
especially from sub-Saharan Africa, while its frequency is not defined in Caucasians. FY* X
allele, associated with Fy (ab+ w) phenotype, has a frequency of 2–3.5% in Caucasian
people while it is absent in Blacks. During the project of extensive blood group genotyping in
patients affected by hemoglobinopathies, we identified FY* X/FY* Null and FY* A/FY* Null …
underlying rare FY* Null and FY* X alleles. FY* Null has a high frequency in Blacks,
especially from sub-Saharan Africa, while its frequency is not defined in Caucasians. FY* X
allele, associated with Fy (ab+ w) phenotype, has a frequency of 2–3.5% in Caucasian
people while it is absent in Blacks. During the project of extensive blood group genotyping in
patients affected by hemoglobinopathies, we identified FY* X/FY* Null and FY* A/FY* Null …
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