Taking into account the vast arrays of fluorinated motifs known, 11 this review will be limited to the monofluorination of organic compounds, ie, synthetic methods allowing the introduction of a single C− F bond. This subject has been the topic of reviews in the past 12 and will overlap with some recent reviews. 11c, 13 The radioisotope labeling with fluorine-18 has been excluded and reviews/perspective on this subject can be found elsewhere. 8, 14 In addition, this review deliberately emphasizes developments that occurred within the last 10 years. Precisely, literature coverage for this review starts from January 1st, 2005 up to December 10th, 2014. For the more traditional synthetic methods, the readers will be referred to various reviews cited in the document. After a brief survey of the approaches for the creation of single C− F bonds, the recent synthetic methods will be classified and reviewed according to the hybridization of the carbon atom bearing the fluorine atom. Within each section, further subclassification according to the targeted fluorinated motif has been used.