Mosaic loss of chromosome Y is associated with common variation near TCL1A
Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs
during aging, particularly in smokers. We investigated whether mLOY was associated with
non-hematological cancer in three prospective cohorts (8,679 cancer cases and 5,110
cancer-free controls) and genetic susceptibility to mLOY. Overall, mLOY was observed in 7%
of men, and its prevalence increased with age (per-year odds ratio (OR)= 1.13, 95%
confidence interval (CI)= 1.12–1.15; P< 2× 10− 16), reaching 18.7% among men over 80 …
during aging, particularly in smokers. We investigated whether mLOY was associated with
non-hematological cancer in three prospective cohorts (8,679 cancer cases and 5,110
cancer-free controls) and genetic susceptibility to mLOY. Overall, mLOY was observed in 7%
of men, and its prevalence increased with age (per-year odds ratio (OR)= 1.13, 95%
confidence interval (CI)= 1.12–1.15; P< 2× 10− 16), reaching 18.7% among men over 80 …
Mosaic loss of chromosome Y is associated with common variation near TCL1A.
ZWY Zhou WeiYin, MJ Machiela, ND Freedman… - 2016 - cabidigitallibrary.org
Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs
during aging, particularly in smokers. We investigated whether mLOY was associated with
non-hematological cancer in three prospective cohorts (8,679 cancer cases and 5,110
cancer-free controls) and genetic susceptibility to mLOY. Overall, mLOY was observed in 7%
of men, and its prevalence increased with age (per-year odds ratio (OR)= 1.13, 95%
confidence interval (CI)= 1.12-1.15; P< 2× 10-16), reaching 18.7% among men over 80 …
during aging, particularly in smokers. We investigated whether mLOY was associated with
non-hematological cancer in three prospective cohorts (8,679 cancer cases and 5,110
cancer-free controls) and genetic susceptibility to mLOY. Overall, mLOY was observed in 7%
of men, and its prevalence increased with age (per-year odds ratio (OR)= 1.13, 95%
confidence interval (CI)= 1.12-1.15; P< 2× 10-16), reaching 18.7% among men over 80 …
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