… Since then, several new models have been introduced in the basic and translational …
models have been re-evaluated. Here, we will focus only on pancreatic cancer mouse models as …

… an overview of the common transgenic mouse models of pancreatic cancer, to discuss their
… area of mouse models of PDAC. MODELING THE BIOLOGY OF PANCREATIC CANCER IN …

… mouse models (GEMMs) of PDA have been created. We describe how these models have
… We also discuss how mouse models of PDA are being used to develop new therapeutic and …

… ; (2) use of this model for … mouse models of pancreatic cancer has been developed by
introducing additional genetic alterations. While the detailed characteristics of all of these models …

… modeling of most common human tumors, the generation of appropriate mouse models of
pancreatic cancer has … Pancreatic cancer is an almost uniformly fatal disease, accounting for …

… subcutaneous and orthotopic models of pancreatic cancer [15]… killed pancreatic cancer
cells and suppressed pancreatic … that in a genetically engineered mouse model (KPC mice), …

Objective Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia
and vascular dysfunction, which critically impair drug delivery. This study examines the role …

… Much of what we know about pancreatic cancer has come from mouse models of this …
mouse models that phenotypically and genetically recapitulate human pancreatic cancer, as well …

… Here, we have used the KPC mice to investigate why PDA is insensitive to … of pancreatic
tumors in four mouse models: the KPC mice and three distinct tumor transplantation models (12, …

… pancreatic progenitor cells in different mouse models of PDAC and in mice with cerulein-induced
acute pancreatitis… Acinar epithelial explants of mutant mice were used to investigate the …