Traumatic brain injury (TBI) causes secondary biochemical changes that contribute to
subsequent tissue damage and associated neuronal cell death. Neuroprotective treatments
that limit secondary tissue loss and/or improve behavioral outcome have been well
established in multiple animal models of TBI. However, translation of such neuroprotective
strategies to human injury have been disappointing, with the failure of more than thirty
controlled clinical trials. Both conceptual issues and methodological differences between …

Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Despite
extensive preclinical research supporting the effectiveness of neuroprotective therapies for
brain trauma, there have been no successful randomized controlled clinical trials to date. TBI
results in delayed secondary tissue injury due to neurochemical, metabolic and cellular
changes; modulating such effects has provided the basis for neuroprotective interventions.
To establish more effective neuroprotective treatments for TBI it is essential to better …