Normothermic ex vivo kidney perfusion for the preservation of kidney grafts prior to transplantation

JM Kaths, VN Spetzler, N Goldaracena… - JoVE (Journal of …, 2015 - jove.com
Kidney transplantation has become a well-established treatment option for patients with end-
stage renal failure. The persisting organ shortage remains a serious problem. Therefore, the
acceptance criteria for organ donors have been extended leading to the usage of marginal
kidney grafts. These marginal organs tolerate cold storage poorly resulting in increased
preservation injury and higher rates of delayed graft function. To overcome the limitations of
cold storage, extensive research is focused on alternative normothermic preservation …
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