Novel selective histone deacetylase 6 (HDAC6) inhibitors: a patent review (2016-2019)
X He, Z Li, XT Zhuo, Z Hui, T Xie… - Recent patents on anti …, 2020 - ingentaconnect.com
X He, Z Li, XT Zhuo, Z Hui, T Xie, XY Ye
Recent patents on anti-cancer drug discovery, 2020•ingentaconnect.comBackground: Many human diseases are associated with dysregulation of HDACs. HDAC6
exhibits deacetylase activity not only to histone protein but also to non-histone proteins such
as α-tubulin, HSP90, cortactin, and peroxiredoxin. These unique functions of HDAC6 have
gained significant attention in the medicinal chemistry community in recent years. Thus a
great deal of effort has devoted to developing selective HDAC6 inhibitors for therapy with the
hope to minimize the side effects caused by pan-HDAC inhibition. Objective: The review …
exhibits deacetylase activity not only to histone protein but also to non-histone proteins such
as α-tubulin, HSP90, cortactin, and peroxiredoxin. These unique functions of HDAC6 have
gained significant attention in the medicinal chemistry community in recent years. Thus a
great deal of effort has devoted to developing selective HDAC6 inhibitors for therapy with the
hope to minimize the side effects caused by pan-HDAC inhibition. Objective: The review …
Background
Many human diseases are associated with dysregulation of HDACs. HDAC6 exhibits deacetylase activity not only to histone protein but also to non-histone proteins such as α- tubulin, HSP90, cortactin, and peroxiredoxin. These unique functions of HDAC6 have gained significant attention in the medicinal chemistry community in recent years. Thus a great deal of effort has devoted to developing selective HDAC6 inhibitors for therapy with the hope to minimize the side effects caused by pan-HDAC inhibition.
Objective
The review intends to analyze the structural feature of the scaffolds, to provide useful information for those who are interested in this field, as well as to spark the future design of the new inhibitors.
Methods
The primary tool used for patent searching is SciFinder. All patents are retrieved from the following websites: the World Intellectual Property Organization (WIPO®), the United States Patent Trademark Office (USPTO®), Espacenet®, and Google Patents. The years of patents covered in this review are between 2016 and 2019.
Results
Thirty-six patents from seventeen companies/academic institutes were classified into three categories based on the structure of ZBG: hydroxamic acid, 1,3,4-oxadiazole, and 1,2,4-oxadiazole. ZBG connects to the cap group through a linker. The cap group can tolerate different functional groups, including amide, urea, sulfonamide, sulfamide, etc. The cap group appears to modulate the selectivity of HDAC6 over other HDAC subtypes.
Conclusion
Selectively targeting HDAC6 over other subtypes represents two fold advantages: it maximizes the pharmacological effects and minimizes the side effects seen in pan-HDAC inhibitors. Many small molecule selective HDAC6 inhibitors have advanced to clinical studies in recent years. We anticipate the approval of selective HDAC6 inhibitors as therapeutic agents in the near future.
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