Recent advances indicate that there is crosstalk between allergic disorders and nucleic acid
sensing. Triggers that activate inflammatory mechanisms via nucleic acid sensors affect both
allergic phenotypes and anti-viral responses, depending on the timing and the order of
exposure. Viral respiratory infections, such as those caused by the rhinovirus, influenza, and
respiratory syncytial virus, are the most frequent cause of significant asthma exacerbations
through effects mediated predominantly by TLR3. However, agonists of other nucleic acid …