[PDF][PDF] Oxidative stress inhibits growth and induces apoptotic cell death in human U251 glioma cells via the caspase-3-dependent pathway.
XR Liu, YQ Li, C Hua, SJ Li, G Zhao… - European Review for …, 2015 - europeanreview.org
XR Liu, YQ Li, C Hua, SJ Li, G Zhao, HM Song, MX Yu, Q Huang
European Review for Medical & Pharmacological Sciences, 2015•europeanreview.orgRESULTS: The oxidative stress to U251 glioma cells exhibited in a dose-dependent manner
with H2O2 concentrations increasing. The cell viability was considerably decreased and
apoptosis occurred in H2O2 treated cells. A G1 cell cycle arrest and O2–level increase were
found in H2O2 group. Western blot analysis showed a decrease of pro-caspase-3 protein
level and an increase of caspase-3 and PARP level in 300 µM H2O2 treated cells. The
H2O2 induced apoptosis depicted above was significantly restrained by CI …
with H2O2 concentrations increasing. The cell viability was considerably decreased and
apoptosis occurred in H2O2 treated cells. A G1 cell cycle arrest and O2–level increase were
found in H2O2 group. Western blot analysis showed a decrease of pro-caspase-3 protein
level and an increase of caspase-3 and PARP level in 300 µM H2O2 treated cells. The
H2O2 induced apoptosis depicted above was significantly restrained by CI …
RESULTS: The oxidative stress to U251 glioma cells exhibited in a dose-dependent manner with H2O2 concentrations increasing. The cell viability was considerably decreased and apoptosis occurred in H2O2 treated cells. A G1 cell cycle arrest and O2–level increase were found in H2O2 group. Western blot analysis showed a decrease of pro-caspase-3 protein level and an increase of caspase-3 and PARP level in 300 µM H2O2 treated cells. The H2O2 induced apoptosis depicted above was significantly restrained by CI.
CONCLUSIONS: Oxidative stress inhibits growth and induces apoptotic cell death in human U251 glioma cells via the caspase-3-dependent pathway. Mitochondrial pathway might involve in this signaling conduction. These findings are favorable for understanding the mechanisms of oxidative stress-induced apoptosis in U251 glioma cells.
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