PI3K/PTEN signaling in angiogenesis and tumorigenesis
BH Jiang, LZ Liu - Advances in cancer research, 2009 - Elsevier
Phosphatidylinositol 3‐kinase (PI3K) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular
functions such as cell metabolism, proliferation, cell‐cycle progression, and survival. PI3K is
activated by growth factors and angiogenesis inducers such as vascular endothelial growth
factor (VEGF) and angiopoietins. The amplification and mutations of PI3K and the loss of the
tumor suppressor PTEN are common in various kinds of human solid tumors. The genetic …
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular
functions such as cell metabolism, proliferation, cell‐cycle progression, and survival. PI3K is
activated by growth factors and angiogenesis inducers such as vascular endothelial growth
factor (VEGF) and angiopoietins. The amplification and mutations of PI3K and the loss of the
tumor suppressor PTEN are common in various kinds of human solid tumors. The genetic …
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