Endometriosis is a common gynecologic disease defined by the presence of endometrial-
like tissue outside the uterine cavity. While its etiology is largely unknown, accumulating
evidence suggests that inflammation plays a major role. Our objective was to investigate the
association between peripheral blood leukocyte telomere length (LTL) and endometriosis
using data from two large population-based studies, the New England Case-Control Study
(NEC; n= 877) and the National Health and Nutrition Examination Survey (NHANES; n …

Background The link between peripheral blood leukocyte telomere length (LTL) and
endometriosis has remained uncertain. In order to investigate this association, a two-sample
Mendelian randomization (MR) analysis was performed. Methods We extracted Single-
nucleotide polymorphisms (SNPs) associated with LTL from a published genome-wide
association study (GWAS) comprising 472,174 individuals. Data on endometriosis, including
its seven subtypes, were sourced from the iue open gwas project. Four methods were …