Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug …
JP van den Berg, HEM Vereecke… - BJA: British Journal …, 2017 - academic.oup.com
BJA: British Journal of Anaesthesia, 2017•academic.oup.com
This review describes the basics of pharmacokinetic and pharmacodynamic drug
interactions and methodological points of particular interest when designing drug interaction
studies. It also provides an overview of the available literature concerning interactions, with
emphasis on graphic representation of interactions using isoboles and response surface
models. It gives examples on how to transform this knowledge into clinically and
educationally applicable (bedside) tools.
interactions and methodological points of particular interest when designing drug interaction
studies. It also provides an overview of the available literature concerning interactions, with
emphasis on graphic representation of interactions using isoboles and response surface
models. It gives examples on how to transform this knowledge into clinically and
educationally applicable (bedside) tools.
This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning interactions, with emphasis on graphic representation of interactions using isoboles and response surface models. It gives examples on how to transform this knowledge into clinically and educationally applicable (bedside) tools.
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