… Abstract: Background: In clinical pharmacokinetic (PK) studies, pregnant women are …
became instrumental to explore and quantify the impact of PK changes during pregnancy. …

… This option is noted in the FDA guidance document, ‘‘Pharmacokinetics in Pregnancy—…
pregnant women in phase III, it anticipates that the majority of PK studies in pregnant women …

… stages of pregnancy and the postpartum period. There are several available approaches
to studying pharmacokinetic changes in pregnancy. Single trough screening studies can …

… This review will briefly outline how pregnancy influences … pharmacokinetic data for
antiretrovirals in pregnant women. … pregnancy and no pharmacokinetic data in pregnant women …

… a study examining pharmacokinetic parameters of cytotoxic drugs in pregnancy. Firstly, we
designed a pregnant baboon model to test gestational effects on pharmacokinetics. Because …

… of pharmacokinetic studies in pregnant women published since 2008 (81 studies) revealed
… the number of pharmacokinetic studies performed in pregnant women are exceedingly low, …

… the pharmacokinetics of a number of drugs has now been investigated in pregnant women.
… of obtaining these data when pharmacokinetic studies in pregnant women must obviously be …

… erence in pharmacokinetics between pregnant women and … t1/2 of pethidine in pregnant
women.This may have clinical … pharmacokinetics of analgesics in pregnancy (even studies of …

… pharmacokinetic studies in pregnant women are neither desirable nor feasible, physiologically
based pharmacokinetic (… pharmacokinetics of drugs in pregnancy. First attempts to build …

… 48 h sampling pharmacokinetics of pregnant women to the non-pregnant subjects with 48 h
… of 3 comparator studies. Our Vss was not significantly different compared to all three studies. …