Pharmacometrics to characterize innate immune response and antibacterial treatments
A Thorsted - 2020 - diva-portal.org
2020•diva-portal.org
… In this work, assessment of immune-response time-courses and anti-bacterial treatments
is made by use of non-linear mixed effects models. … Further, in vitro bacterial release of
lipopolysaccharide (LPS), a bacterial product that stimulates the innate mammalian immune
response, was linked to natural bacterial growth and antibiotic-induced killing. … The
models developed in this thesis adds significantly to the quantitative understanding of time-courses
in relation to host immune response, bacteria and antibacterial treatments. …
is made by use of non-linear mixed effects models. … Further, in vitro bacterial release of
lipopolysaccharide (LPS), a bacterial product that stimulates the innate mammalian immune
response, was linked to natural bacterial growth and antibiotic-induced killing. … The
models developed in this thesis adds significantly to the quantitative understanding of time-courses
in relation to host immune response, bacteria and antibacterial treatments. …
Abstract
Thorsted, A. 2020. Pharmacometrics to characterize innate immune response and antibacterial treatments. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of
diva-portal.org
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