Poly (A), poly (A) binding protein and the regulation of mRNA stability
P Bernstein, J Ross - Trends in biochemical sciences, 1989 - cell.com
P Bernstein, J Ross
Trends in biochemical sciences, 1989•cell.comGene expression can be controlled by changing the half-lifes of specific mRNAs in response
to intracellular events or to extracellular stimuli. Many experiments suggest that mRNA
turnover in mammalian cells is linked to poly (A) metabolism, which might be affected by the
efficiency of the cytoplasmic poly (A) binding protein in protecting poly (A) from nucleolytic
attack. Most newly synthesized mRNAs are modified post-transcriptionally by the addition of
a poly (A) tract at their 3'termini. Although the detailed mechanisms of poly (A) synthesis are …
to intracellular events or to extracellular stimuli. Many experiments suggest that mRNA
turnover in mammalian cells is linked to poly (A) metabolism, which might be affected by the
efficiency of the cytoplasmic poly (A) binding protein in protecting poly (A) from nucleolytic
attack. Most newly synthesized mRNAs are modified post-transcriptionally by the addition of
a poly (A) tract at their 3'termini. Although the detailed mechanisms of poly (A) synthesis are …
Gene expression can be controlled by changing the half-lifes of specific mRNAs in response to intracellular events or to extracellular stimuli. Many experiments suggest that mRNA turnover in mammalian cells is linked to poly (A) metabolism, which might be affected by the efficiency of the cytoplasmic poly (A) binding protein in protecting poly (A) from nucleolytic attack.
Most newly synthesized mRNAs are modified post-transcriptionally by the addition of a poly (A) tract at their 3'termini. Although the detailed mechanisms of poly (A) synthesis are being elucidated, the functions of poly (A) are not fully understood. The poly (A) tract might have multiple functions, both in the nucleus and the cytoplasm: it might play a role in the processing and transport of mRNA (for: review see
cell.com
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