Osteoporosis (OP) is a skeletal disorder characterized by decreased bone density, alterations in bone microstructure, and increased damage to the bones. As the population ages and life expectancy increases, OP has become a global epidemic, drawing attention from scientists and doctors. Because of polyphenols have favorable antioxidant and anti-allergy effects, which are regarded as potential methods to prevent angiocardipathy and OP. Polyphenols offer a promising approach to preventing and treating OP by affecting bone metabolism, reducing bone resolution, maintaining bone density, and lowering the differentiation level of osteoclasts(OC). There are multiple ways in which polyphenols affect bone metabolism. This article provides an overview of how polyphenols inhibit oxidative stress, exert antibacterial effects, and prevent the occurrence of OP. Furthermore, we will explore the regulatory mechanisms and signaling pathways implicated in this process.

Mini Abstract: Osteoporosis(OP) is a systemic bone disease characterized by a decrease in bone density and quality, resulting in increased bone fragility and a higher risk of fractures. Polyphenols are natural compounds recognized for their antioxidant activity and anti-inflammatory effects. This review aims to explore the molecular mechanisms that underlie the impact of polyphenols on OP.