Population genomics of cardiometabolic traits: design of the university college london-london school of hygiene and tropical medicine-edinburgh-bristol (UCLEB) …

T Shah, J Engmann, C Dale, S Shah, J White… - PloS one, 2013 - journals.plos.org
… variants influencing cardiometabolic traits and disease outcomes through genome wide …
new questions have arisen regarding the population relevance, mechanisms, and applications …

[PDF][PDF] Population Genomics of Cardiometabolic Traits: Design of the University College London

T Shah, J Engmann, C Dale, S Shah, J White - 2013 - Citeseer
… variants influencing cardiometabolic traits and disease outcomes through genome wide …
new questions have arisen regarding the population relevance, mechanisms, and applications …

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity

V Baltramonaityte, JB Pingault, CAM Cecil… - … genetics, 2023 - journals.plos.org
… cross-trait liability to psycho-cardiometabolic diseases. We used genomic structural equation
… For detailed characteristics of the input populations and the sources of data see S1 Table. …

The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits

BF Voight, HM Kang, J Ding, CD Palmer, C Sidore… - 2012 - journals.plos.org
… the genome-wide significant loci by fine-mapping, we designedpopulations by leaving one
individual out from the 1000 … a shared genetic etiology between these cardiometabolic traits. …

Genetic regulation of adipose gene expression and cardio-metabolic traits

M Civelek, Y Wu, C Pan, CK Raulerson, A Ko… - … of Human Genetics, 2017 - cell.com
… We performed expression quantitative trait locus (eQTL) analyses by using abdominal … 680
known genome-wide association study (GWAS) loci for cardio-metabolic traits, we identified …

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

…, European Network for Genetic and Genomic … - PLoS …, 2013 - journals.plos.org
cardiometabolic traits, and between BMI and the same traits using genetic and health data
collected in 36 population-… In this large-scale meta-analysis, we used a MR design to examine …

Genome-wide characterization of circulating metabolic biomarkers

S Karthikeyan, C Oliver-Williams, E Sliz, E Allara… - Nature, 2024 - research.ed.ac.uk
… that, in addition to subtle differences in population ancestry between the studies, sample type
… has been associated with several cardiometabolic conditions including heart failure55 and …

[HTML][HTML] The 'ALSPAC in London'dataset: adiposity, cardiometabolic risk profiles, and the emerging arterial phenotype in young adulthood

ST Chiesa, A Rapala, M Charakida… - Wellcome Open …, 2018 - wellcomeopenresearch.org
… greatest threats to future population burden of cardiovascular … Using a novel ‘recall-by-genotype’
study design to identify … % from the upper tail of the genome-wide GRS distribution The …

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

…, MI McCarthy, Early Growth Genetics Consortium… - … genetics, 2020 - journals.plos.org
population stratification or cryptic relatedness or other confounders was observed (genomic
childhood BMI with several anthropometric and cardio-metabolic traits, including adult BMI (…

Predicted Deleterious Variants in Cardiomyopathy Genes Prognosticate Mortality and Composite Outcomes in the UK Biobank

B Asatryan, RA Shah, G Sharaf Dabbagh… - Heart Failure, 2024 - jacc.org
College of Medical Genetics and Genomics (ACMG) list for reporting of secondary findings in
clinical exome and genome … of the general population at higher genomic risk for developing …