[HTML][HTML] Population-based analysis of ocular Chlamydia trachomatis in trachoma-endemic West African communities identifies genomic markers of disease severity
Abstract Background Chlamydia trachomatis (Ct) is the most common infectious cause of
blindness and bacterial sexually transmitted infection worldwide. Ct strain-specific
differences in clinical trachoma suggest that genetic polymorphisms in Ct may contribute to
the observed variability in severity of clinical disease. Methods Using Ct whole genome
sequences obtained directly from conjunctival swabs, we studied Ct genomic diversity and
associations between Ct genetic polymorphisms with ocular localization and disease …
blindness and bacterial sexually transmitted infection worldwide. Ct strain-specific
differences in clinical trachoma suggest that genetic polymorphisms in Ct may contribute to
the observed variability in severity of clinical disease. Methods Using Ct whole genome
sequences obtained directly from conjunctival swabs, we studied Ct genomic diversity and
associations between Ct genetic polymorphisms with ocular localization and disease …
[PDF][PDF] Population-based analysis of ocular Chlamydia trachomatis in trachoma-endemic West African communities identifies genomic markers of disease severity
HMB Seth-Smith, J Hadfield, LT Cutcliffe… - 2018 - genomemedicine.biomedcentral …
Abstract Background: Chlamydia trachomatis (Ct) is the most common infectious cause of
blindness and bacterial sexually transmitted infection worldwide. Ct strain-specific
differences in clinical trachoma suggest that genetic polymorphisms in Ct may contribute to
the observed variability in severity of clinical disease. Methods: Using Ct whole genome
sequences obtained directly from conjunctival swabs, we studied Ct genomic diversity and
associations between Ct genetic polymorphisms with ocular localization and disease …
blindness and bacterial sexually transmitted infection worldwide. Ct strain-specific
differences in clinical trachoma suggest that genetic polymorphisms in Ct may contribute to
the observed variability in severity of clinical disease. Methods: Using Ct whole genome
sequences obtained directly from conjunctival swabs, we studied Ct genomic diversity and
associations between Ct genetic polymorphisms with ocular localization and disease …
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