Preaddiction—a missing concept for treating substance use disorders

AT McLellan, GF Koob, ND Volkow - JAMA psychiatry, 2022 - jamanetwork.com
Background The centuries-old term addiction remains widely used in both professional and
popular media because it communicates commonly held imagery of those whose once-
promising lives were ruined by their uncontrolled use of substances, such as alcohol,
opioids, or stimulants. In the scientific literature, addiction was once considered a personality
disorder and later, the manifestation of tolerance and withdrawal from hard drug use.
However, scientific findings now suggest impaired control as the core defining diagnostic …
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