Prediction of MHC class II binders using the ant colony search strategy
OBJECTIVE:: Predictions of the binding ability of antigen peptides to major histocompatibility
complex (MHC) class II molecules are important in vaccine development. The variable
length of each binding peptide complicates this prediction. METHODOLOGY:: Motivated by
the search properties of the ant colony system (ACS), a method for the identification of an
alignment for a given set of short protein peptides has been developed. This alignment is
further used for the derivation of a position specific scoring matrix. The distinguishing feature …
complex (MHC) class II molecules are important in vaccine development. The variable
length of each binding peptide complicates this prediction. METHODOLOGY:: Motivated by
the search properties of the ant colony system (ACS), a method for the identification of an
alignment for a given set of short protein peptides has been developed. This alignment is
further used for the derivation of a position specific scoring matrix. The distinguishing feature …
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