Spherical bimetallic cobalt-lanthanum oxides were loaded on the surface of electrospun carbon fiber by simple hydrothermal method and an electrochemical sensor was successfully constructed for simultaneous detection of amlodipine and acetaminophen. Carbon fiber, as an electron transport channel, is cooperated with bimetallic oxides to provide uniformly dispersed active sites and enhance the conductivity of the composite. The linear relationships between amlodipine and acetaminophen are 10-1000 µM and 5-1600 µM, and the detection limits are 0.86 µM and 0.25 µM, respectively. Furthermore, experiments reveal that the sensor exhibits good stability, and satisfactory recovery rate has been obtained in the detection of two practical drugs.