Oral mucositis is a distressing toxic effect of systemic chemotherapy with many commonly
utilized drugs and of head and neck irradiation in patients with cancer. The agents and
methods that have been used and studied in chemotherapy-and radiotherapy-induced oral
mucositis, their mechanisms of action, and the current knowledge of their efficiency to
reduce the incidence, severity or shorten the duration of oral mucositis are reviewed in this
article. Oral cooling is a cheap and available method to lower the severity of bolus 5 …

Background and objectives: Oral mucositis is one of the main adverse events of cancer
treatment with chemotherapy or radiation therapy. It presents as erythema, atrophy or/and
ulceration of oral mucosa. It occurs in almost all patients, who receive radiation therapy of
the head and neck area and from 20% to 80% of patients who receive chemotherapy. There
are few clinical trials in the literature proving any kind of treatment or prevention methods to
be effective. Therefore, the aim of this study is to perform systematic review of literature and …