To prospectively assess the applicability of reduced-intensity conditioning hematopoietic
stem cell transplantation (RIC-HSCT), we wrote a protocol in which all untreated patients 50
years or older with acute myeloid leukemia (AML) and unfavorable cytogenetics would be
evaluated during induction for a possible RIC-HSCT in first complete remission (CR1).
Ninety-nine of 259 patients entered CR. Fifty-three of the 99 were seen by the Transplant
Service with the remainder not seen because of illness, lack/unavailability of siblings …

To prospectively assess the applicability of reduced intensity transplantation (RICHSCT) we
wrote a protocol in which all untreated patients age≥ 50 with AML and unfavorable
cytogenetics would be evaluated during induction for a possible RIC-HSCT in first CR
(CR1). 99 of 259 patients entered CR. 53 of the 99 were seen by the Transplant Service with
the remainder not seen because of illness, lack/unavailability of siblings, refusal, or,
primarily, unclear reasons (21 patients). A donor was identified for 26 patients (21 sibling, 5 …